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KMID : 0978920120130020160
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Korean Journal of Clinical Geriatrics
2012 Volume.13 No. 2 p.160 ~ p.167
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Diabetic Peripheral Neuropathic Pain: Clinical and Quality-of-Life
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Lee Dong-Kuck
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Abstract
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Diabetic peripheral polyneuropathy (DPN) is one of the most common long-term complications of diabetes, characterized by progressive sensory loss predisposing to neuropathic foot ulceration and associated with premature mortality. DPN is associated in some patients with neuropathic pain that responds poorly to conventional analgesics. Despite its clear typical clinical expression, neuropathic pain still goes underdiagnosed. A DPN prevalence rate as high as 50% has been reported in the literature, but there are considerable differences across studies, which may be due to methodological differences and the lack of consensus on its diagnostic criteria. Although most patients with DPN do not have pain, approximately 11% of patients with DPN have chronic, painful symptoms that diminish quality of life, disrupt sleep, and can lead to depression. Despite the number of patients affected by DPN pain, little consensus exists about the pathophysiology, best diagnostic tools, and primary treatment choices.
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KEYWORD
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Diabetic peripheral neuropathy, Clinical, Quality-of-life
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